multiple myeloma in iran

But when you have myeloma, those cells El Husseiny NM, Kasem N, El Azeeim HA, Mattar MW. Reimer RR, Hoover R, Fraumeni JF, Young RC. (Fig.11). Bethesda, MD 20894, Web Policies If they relapse, there was no specific reimbursable combination. Sadia S, Syed M, Saira P, Ali H, Basharat M. Multiple Myeloma: a Retrospective Analysis of 61 Patients from a Tertiary Care Center. The initial data for this retrospective cohort survey were derived from ambulance cards, hospitalization journals, and clinical data from the Registry of Blood Diseases at the Yeolyan Hematology Center. The most common laboratory finding is anemia (45.6%). 2003 Jun;3(3):311-29. doi: 10.1586/14737140.3.3.311. Banaszkiewicz M, Mayszko J, Vesole DH, Woziwodzka K, Jurczyszyn A, rawski M, Krzanowski M, Mayszko J, Batko K, Kuniewski M, Krzanowska K. J Clin Med. Jafari-Delouei N, Naimi-Tabiei M, Farajollahi M, Sedaghat SM, Khandoozi S, Ghasemi-Kebria F, Dinparastisaleh R, Pourkhani A, Roshandel G. Arch Iran Med. Epub 2017 Nov 22. Ramn V, Ingemar T, Ola L, et al. The https:// ensures that you are connecting to the Multiple Myeloma Treatment in Real-world Clinical Practice: Results of a Prospective, Multinational, Noninterventional Study. The mean and median survival for each type is shown in table 2. Tan D, Chng WJ, Chou T, et al. Thus, combining various drugs such as bortezomib, dexamethasone, lenalidomide, and melphalan with compounds that are not common, including CTY387, LLL-12, OPB31121, CNTO328, OSI-906, FTY720, triptolide, and AV-65, could be one of the most effective treatments for these patients. There was mild suppression of haemopoiesis. The aim of this study is to review the department registry of multiple myeloma patients at Jordan University Hospital (JUH), which is representative of the whole country, over eight years with patient characteristics and disease patterns, survival, and therapy used in a real-world experience. The introduction of autologous hematopoietic stem cell transplantation has positively impacted overall survival. Obesity or being overweight is also linked with a higher risk of most types of cancerthis includes multiple myeloma. Please enable it to take advantage of the complete set of features! The patients received melphalan and prednisolone (MP), cyclophosphamide and prednisolone (CP), vincristine, doxorubicin, and dexamethasone (VAD) and also according to new protocols other treatment such as (Cyclophosphamide, bortezomib, Doxorubicin and Dexamethasone (CVDD) [1, 21, 29]. Signs and symptoms of multiple myeloma can vary and, early in the disease, there may be none. Review/update the This is a non-interventional and retrospective analysis of the MM registry from 2009-to 2016 involving 113 patients at JUH. Careers. Survival as per stage and the abnormal IgG and IgA paraprotein detected. The Key Role of Hepcidin-25 in Anemia in Multiple Myeloma Patients with Renal Impairment. The combat against hematological malignancies is primarily aimed at reducing prevalence, incidence, mortality and improving the quality of life of cancer patients through prevention, early diagnosis, effective therapy and palliative care. A Rare Presentation of an Aggressive Case of Secondary Plasma Cell Leukaemia. .st3 { Clipboard, Search History, and several other advanced features are temporarily unavailable. The https:// ensures that you are connecting to the 2022 Dec 7;23(24):15448. doi: 10.3390/ijms232415448. National Comprehensive Cancer Network. Epub 2008 Dec 1. 2018 May 15;200(10):3485-3494. doi: 10.4049/jimmunol.1700787. As a library, NLM provides access to scientific literature. Network pharmacology- and molecular docking-based investigation of the therapeutic potential and mechanism of daucosterol against multiple myeloma. Anemia of chronic disease: a unique defect of iron recycling for many different chronic diseases. Bookshelf A total of 11 cycles were completed. FOIA Lancet Oncology. Bookshelf Information about follow up was also taken from these sources. A number of studies have reported increasing MM incidence over time in the world as well [2, 4, 9, 11, 21, 23]. The .gov means its official. Obesity or Being Overweight. Asian Pacific Organization for Cancer Prevention. This content does not have an English version. government site. Hypercalcemia was slightly higher in the European countries study, which was reported in 19% of patients.18, 73.5% of our patients had osteolytic lesions by imaging (shown in table 1), comparable to the Swedish study (77%).16. Subjects who had autologous bone marrow transplantation were given monthly bortezomib post-ABMT maintenance for one year. Al-Sayaideh Ayoub, Nimri Omar, Arqoub Kamal, Al-Zaghal Marwan, Halasa Wafa. Plasma cells are morphologically easy to identify in bone marrow, however, they are often missed on peripheral blood smear examination. Among hematological malignancies, in terms of frequency, MM is the second, following lymphomas, and accounts for 1% of all neoplasias, 2% of all deaths from neoplasias and 1215% of onco-hematological diseases [111]. FNA smears from scalp swelling showed dispersed population of plasma cells with eccentric nucleus, perinuclear hof and basophilic cytoplasm [Table/Fig-1d]. Hepcidin levels are increased systemically and this hormone acts on its receptor/iron exporter ferroportin to block the efflux of iron from the reticuloendothelial system and from enterocytes. WebLow blood counts. WebOverview If you have been diagnosed with multiple myeloma or are worried about it, you likelyhave a lot of questions. Overall survival for the 20062009, 20102013, 20142018 period of follow-up for patients with multiple myeloma in Armenia (1- and 5-year estimates with 95% confidence level), *<0.05; Comparison of age60 and>60, Kaplan-Meier curves according to the age and sex of the patients. WebQu es el mieloma mltiple? Make your tax-deductible gift and be a part of the cutting-edge research and care that's changing medicine. We expect the following decade to show better survival and quality of life for MM patients once these drugs are widely used. Remember, no two people are entirely alike. Background showed lymphocytes and blood. official website and that any information you provide is encrypted 85.2% of the patients were treated using DT, while 14.8% were treated using VDT (Table 2). Katodritou et al., demonstrated that patients treated with bortezomib versus conventional therapies had a higher survival of 13 months versus 2 months and also high response rates [10]. Epidemiology of MM is similar to the leukemias. ErrorSelect This site needs JavaScript to work properly. Overall survival (OS) was analyzed with the Kaplan-Meier method. Prevalence, incidence and survival of smoldering multiple myeloma in the United States. Patient is on monthly follow up. : +9626535000. What Is Multiple Myeloma? Multiple myeloma (adult). Blood. Disclaimer. As for the ISS stage, 27.4% were stage I, 36.28% were stage II, and 36.28 were stage III. Distress management. (b) Plasma cells in bone marrow aspirate. Accessibility government site. Kyle RA, et al. Trends in utilization and outcomes of autologous transplantation as early therapy for multiple myeloma. Pathways of Angiogenic and Inflammatory Cytokines in Multiple Myeloma: Role in Plasma Cell Clonal Expansion and Drug Resistance. Complete haemogram, SPEP and Fine Needle Aspiration (FNA) of the swelling were advised. The incidence of leukemia was significantly higher in males and residents of rural areas. Click here for an email preview. The authors declare that they have no competing interests. 2016; doi:10.1016/S1470-2045(16)30206-6. 2020 Jan-Feb;10(1):58-69. Accessed Sept. 1, 2020. National Library of Medicine Unable to load your collection due to an error, Unable to load your delegates due to an error. First, a possible explanation that we have an increase in the incidence could be improvements in MM diagnosis in Armenia. Would you like email updates of new search results? information highlighted below and resubmit the form. Molecular Features of the Mesenchymal and Osteoblastic Cells in Multiple Myeloma. information and will only use or disclose that information as set forth in our notice of Kristinsson SY, Anderson WF, Landgren O. Presence of plasma cells can be confirmed by flowcytometric evaluation demonstrating strong positivity for CD38 and CD138. Materials and methods: Antibodies Targeting the Transferrin Receptor 1 (TfR1) as Direct Anti-cancer Agents. Journal of Clinical and Diagnostic Research : JCDR. Lack of CD56 may be associated with More extramedullary disease [8]. Transferrin-a modulates hepcidin expression in zebrafish embryos. Case presentation . Healthy plasma cells help you fight infections by making antibodies that recognize and attack germs. All the 502 patients in our study were Indo-European/Armenians and 75% of the patients were older than 55years (Table (Table1).1). With 128 cases in our registry during the same period, it seems that it captured (27.6%) of all myeloma cases in Jordan, which makes it very representative of the disease in the country. We found that the average annual incidence was 1.2 per 100,000 population during 20062018 period. Multiple myeloma almost always starts out as a relatively benign condition called monoclonal gammopathy of undetermined significance (MGUS). sharing sensitive information, make sure youre on a federal https://www.nccn.org/professionals/physician_gls/f_guidelines.asp. 3, Table Table22). Figure 2 demonstrates the survival difference between treatment regimens used. Liwing J, Uttervall K, Lund J, Aldrin A, Blimark C, Carlson K, Enestig J, Flogegrd M, Forsberg K, Gruber A, Haglf Kviele H, Johansson P, Lauri B, Mellqvist UH, Swedin A, Svensson M, Nsman P, Alici E, Gahrton G, Aschan J, Nahi H. Improved survival in myeloma patients: starting to close in on the gap between elderly patients and a matched normal population. Mediterranean Journal of Hematology and Infectious Diseases, https://creativecommons.org/licenses/by-nc/4.0, https://openknowledge.worldbank.org/bitstream/handle/10986/34496/9781464816024.pdf, https://www.worldbank.org/en/country/jordan/brief/qa-jordan-country-reclassification. Geographical and ecological analyses of multiple myeloma in Denmark: Identification of potential hotspot areas and impact of urbanisation. eCollection 2017. June 24, 2020. Efficacy and Mechanism of Antitumor Activity of an Antibody Targeting Transferrin Receptor 1 in Mouse Models of Human Multiple Myeloma. eCollection 2021 Feb. Kabir MT, Rahman MH, Akter R, Behl T, Kaushik D, Mittal V, Pandey P, Akhtar MF, Saleem A, Albadrani GM, Kamel M, Khalifa SAM, El-Seedi HR, Abdel-Daim MM. official website and that any information you provide is encrypted Tropolone-induced effects on the unfolded protein response pathway and apoptosis in multiple myeloma cells are dependent on iron. Real-world data on 4904 patients from the Swedish Myeloma Registry. There was a statistical significance concerning ISS stages (p < 0.05). Association between treatment facility volume and mortality of patients with multiple myeloma. HHS Vulnerability Disclosure, Help Myeloma incidence statistics. Before Overall survival was determined by the period between the date of diagnosis and the date of death. Potential Role of Curcumin and Its Nanoformulations to Treat Various Types of Cancers. The site is secure. The https:// ensures that you are connecting to the AS: drafting of the manuscript and recruitment of participants. Pulte D, Jansen L, Castro FA, Emrich K, Katalinic A, Holleczek B, Brenner H, the GEKID Cancer Survival Working Group Trends in survival of multiple myeloma patients in Germany and the United States in the first decade of the 21st century. Protons are pumped into the endosome resulting in a decrease in pH that stimulates a conformational change in Tf and its subsequent release of iron. Survival curves are shown in figures 1 and and2.2. Treatment for multiple myeloma isn't always necessary right away. MeSH Bethesda, MD 20894, Web Policies In addition, in Armenia, under the Ministry of Health, there is a program called e-health, to which all medical institutions in Armenia are connected, and any medical event with the patient is introduced from everywhere in this program. The median age was 60.6years (range 3189) with 260 (51.8%) female and 242 (48.2%) male patients.

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